Principal Cloud Engineer, Infrastructure | Onsite San Diego HQ
Who We Are: Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. (*in collaboration with AbbVie) About the Role: The Principal Cloud and Infrastructure Engineer serves as the senior technical expert responsible for designing, modernizing, and optimizing enterprise-scale hybrid cloud environments across Azure, AWS, and on-premises infrastructure. This role leads cloud transformation initiatives including migration, automation, infrastructure modernization, FinOps optimization, and secure platform engineering while establishing architectural standards for scalability, reliability, compliance, and operational excellence. The position requires deep expertise in Azure cloud services, hybrid infrastructure, virtualization, networking, identity management, Infrastructure as Code (IaC), and container platforms, along with the ability to lead cross-functional initiatives and mentor engineering teams in highly regulated enterprise environments. _ Your Contributions (include, but are not limited to): Cloud Architecture & Infrastructure Modernization Lead enterprise-scale cloud transformation initiatives, including infrastructure consolidation, virtualization, hybrid cloud modernization, and migration strategies across Azure, AWS, and on-prem environments Architect scalable, resilient, and highly available cloud infrastructure solutions aligned with business, security, and compliance requirements Design and implement hybrid connectivity architectures leveraging Azure ExpressRoute, VPN, SD-WAN, private endpoints, and secure access technologies Develop disaster recovery, business continuity, and high-availability strategies across cloud and datacenter platforms Platform Engineering & Automation Champion automation-first engineering practices using Infrastructure as Code (IaC) technologies including Terraform, ARM/Bicep, and CloudFormation Design and implement API-driven, self-service infrastructure provisioning platforms integrated with ServiceNow, identity platforms, and CI/CD pipelines Standardize and automate infrastructure deployment, configuration management, patching, monitoring, and lifecycle operations Lead adoption of modern platform engineering practices supporting scalable and repeatable infrastructure delivery Cloud Operations, Optimization & FinOps Lead cloud governance, cost optimization, and FinOps initiatives across Azure and AWS environments, including consumption analysis, reserved instance strategies, rightsizing, and budgeting controls Establish operational standards for monitoring, observability, performance tuning, and incident response across hybrid infrastructure Optimize storage and compute utilization through lifecycle management, automated tiering, and workload balancing strategies Drive continuous improvement initiatives to enhance reliability, scalability, operational efficiency, and service performance Compute, Storage & Virtualization Architect and optimize VMware infrastructure platforms with a focus on footprint reduction, operational efficiency, resiliency, and automation Design scalable enterprise storage solutions across Azure, AWS (S3, FSx), and NetApp environments, including backup, replication, and lifecycle governance Enable secure, scalable compute platforms supporting containerized workloads, Kubernetes orchestration, analytics platforms, and modern application hosting requirements Security & Identity Integration Implement identity-driven access models using Active Directory, Azure AD/Entra ID, RBAC, and policy-based provisioning frameworks Integrate security best practices into all cloud and infrastructure architectures, including zero-trust principles, segmentation, encryption, and secure access controls Ensure compliance with enterprise security, audit, and regulatory standards across cloud and on-prem environments Collaborate with cybersecurity teams to implement governance policies, risk mitigation controls, and infrastructure hardening standards Leadership & Cross-Functional Collaboration Provide technical leadership, mentorship, and strategic guidance to cloud and infrastructure engineering teams Partner with application, security, networking, and enterprise architecture teams to deliver scalable cloud solutions aligned with organizational goals Serve as a subject matter expert for cloud architecture, hybrid infrastructure, automation, and platform engineering initiatives Evaluate emerging technologies, industry trends, and Microsoft Azure innovations to recommend and drive modernization and continuous improvement Requirements: High School Diploma, GED, or equivalent and 10+ years of equivalent experience, training, or certifications OR Bachelor's degree in Computer Science, Information Technology, or related field and 6+ years of hybrid technology infrastructure engineering experience with 4+ years focused on Azure services OR Master's degree in Computer Science, Information Technology, or related field and 4+ years of experience as listed above OR Certifications such as Azure Certified Solutions Architect, Azure Certified DevOps Engineer, or equivalent Extensive experience managing enterprise hybrid infrastructure environments across on-premises, Azure, and multi-cloud platforms, including support for scientific and high-performance computing (HPC) workloads Deep expertise in Microsoft Azure cloud services, including Entra ID, Virtual Desktop Infrastructure (VDI), Storage, SQL, networking, governance, and security services Strong proficiency with Infrastructure as Code (IaC) and automation frameworks such as Terraform, ARM/Bicep, and CloudFormation Advanced knowledge of hybrid cloud architecture, infrastructure integration, and enterprise platform modernization strategies Proven experience designing, deploying, and optimizing scalable HPC and analytics platforms in cloud and hybrid environments Hands-on experience with enterprise storage architectures across Azure and on-premises platforms, including performance optimization, lifecycle management, and data protection strategies Familiarity with scientific computing applications, research platforms, and data-intensive workloads in regulated environments Strong understanding of datacenter operations, virtualization technologies (VMware), backup/recovery, and infrastructure resiliency practices Experience implementing cloud security best practices, identity and access management, governance controls, and compliance standards across hybrid environments Demonstrated leadership, communication, and cross-functional collaboration skills with experience mentoring engineers and partnering with technical and business stakeholders Understands key business drivers and uses this understanding to accomplish work Has strong understanding of processes, procedures and systems used to accomplish the work and recognizes downstream impact on other functional areas Proficient with tools and processes that support work conducted by functional area Ability to work as part of a team; may train lower levels Excellent computer skills Strong communications, problem-solving, analytical thinking skills Detail oriented yet can see broader picture for department Ability to meet multiple deadlines, with a high degree of accuracy and efficiency Strong project management skills #LI-CL1 Neurocrine Biosciences is an EEO/Disability/Vets employer. We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description. _ The annual base salary we reasonably expect to pay is $132,700.00-$182,000.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 30% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans. We are a top place to work. Neurocrine Biosciences was named one of the FORTUNE Best Workplaces in Biopharma™ 2025. We were also named a Great Place to Work® Certified company. ©2025 Fortune Media IP Limited. All rights reserved. Used under license. OUR VALUES: PASSION: We are driven and love what we do. We are committed to our goals and to making a difference. INTEGRITY: We do the right thing for patients and our community. We take accountability. We speak up. COLLABORATION: We trust one another. We are inclusive. We are respectful. We are transparent. Together we succeed. INNOVATION: We seek and create optimal solutions. TENACITY: We do not quit. We adapt. We accomplish what others cannot. Come join our team during this exciting time of growth and opportunities! Apply tot his job Apply To this Job