Director/Senior Director of Biostatistics
At Pathos, we’re reimagining what’s possible in oncology drug development. Founded by the team that built and scaled Tempus Labs, home to the world’s largest library of clinical and molecular data, Pathos is on a mission to revolutionize precision medicine in cancer. We’re using AI and machine learning not as buzzwords, but as fundamental tools to understand biology, identify precise disease drivers, and match patients to the therapies they truly need. Our vision is bold: to create a new model for drug discovery and development, one rooted in deep data, integrated science, and rapid translation. We’re not building another pharma company, we’re building a platform to find better medicines, faster, and to get them to the right patients at the right time. We’ve already begun assembling a portfolio of clinical-stage oncology assets, and we’re applying our technology to select the right indications, optimize clinical design, and increase the probability of success, from bench to bedside. We believe that the current system moves too slowly, and too many patients are still waiting. That’s why we’re here. That’s why Pathos exists. If you’re driven by purpose, excited by complexity, and eager to work alongside brilliant, kind, and mission-aligned teammates, we’d love to meet you. We’re headquartered in New York City, with a distributed team across the U.S., and operate with the focus and agility of a startup while building with the scale and ambition of something much bigger. Come help us build it.
About the Role
The Director/Senior Director of Biostatistics will take ownership of trial-level statistical design, analysis, and regulatory deliverables across our oncology programs. This role reports to the Vice President, Head of Clinical Development, and is ideal for a hands-on biostatistician who thrives on applying rigorous statistical methods to advance clinical development. You will partner closely with clinical, regulatory, and data science colleagues to design and analyze studies, support submissions, and ensure high-quality statistical contributions to key program decisions.
Key Responsibilities
- Lead statistical design and analysis for oncology clinical studies (Phases I–III).
- Develop and review statistical sections of protocols, SAPs, study reports, and regulatory documents.
- Execute and oversee interim and final analyses, ensuring high scientific rigor.
- Apply advanced statistical methodologies (e.g., survival analysis, Bayesian, adaptive designs).
- Collaborate with data management and programming teams to ensure data quality and analysis readiness.
- Support preparation of regulatory submissions and agency interactions (FDA, EMA, etc.).
- Serve as the statistical expert on cross-functional study teams.
- Contribute to developing tools, templates, and best practices for the growing biostatistics function.
What We’re Looking For
- PhD or MS in Biostatistics (or related field).
- 7–12 years of industry experience in biostatistics (oncology preferred).
- Hands-on expertise in clinical trial design, statistical analysis, and regulatory deliverables.
- Strong SAS/R programming skills.
- Demonstrated success with innovative trial methodologies (e.g., adaptive, Bayesian).
- Excellent communicator and collaborator across clinical, regulatory, and data teams.
- Thrives in a dynamic, fast-paced.
Location The preferred location for this position is our New York City headquarters, although exceptional remote candidates will also be considered.
What We Offer
- Competitive salary and equity package
- Comprehensive health, dental, and vision insurance
- Flexible PTO and remote work options
- Professional development budget
- Opportunity to build something from scratch and have a massive impact
- Collaborative, innovative work environment
Apply tot his job Apply To this Job